As an important overpressure safety discharge device, sanitary rupture disk has the characteristics of rapid response, good sealing, and wide range of applicable media. It plays an important role in the safe production of the pharmaceutical industry. A variety of hazardous processes and special media will be involved in the pharmaceutical production process. Through the precise overpressure relief function, the sanitary rupture disk can effectively prevent safety accidents such as equipment explosion and media leakage, and ensure the safety of production personnel and production continuity.
Chemical synthesis is an important part of pharmaceutical production. Most APIs are prepared through chemical reactions. The preparation process is often accompanied by pressure fluctuations, exothermic reactions or gas generation, and there is a risk of overpressure. For example, in the synthesis of antibiotics, the metabolism of microorganisms in the fermentation tank will produce a large amount of gas. If the mixing system fails or the exhaust pipe is blocked, the pressure in the tank will suddenly increase. The sanitary rupture disk can break instantly when these devices are overpressure, quickly releasing pressure. In addition, the sanitary rupture disk adopts a leak-free design, which can ensure the sealing of the reaction system and prevent the reactant from contaminating or deteriorating due to contact with the outside world.
The production of sterile preparations has extremely high environmental requirements and needs to be completed through a closed system in a sterile clean room. Aseptic filling equipment, sterilization cabinets, freeze-drying machines and other equipment will involve pressure changes during operation. If the pressure is not controlled properly, it may destroy the sterile environment or cause equipment damage. In the sterilization cabinet, a specific pressure and temperature need to be maintained when steam sterilization is used. If the pressure sensor fails or the exhaust valve fails, the pressure in the cabinet may be too high, affecting the sterilization effect and even causing an explosion. The sanitary rupture disk is installed at the pressure relief port of the sterilization cabinet, which can act immediately when the pressure exceeds the safe value to ensure the safety of the sterilization process. In the freeze-drying machine, the failure of the vacuum system may cause the pressure in the cavity to increase abnormally. The sanitary rupture disk can quickly release the pressure and protect the equipment and internal medicines.
Some raw materials and intermediates in the pharmaceutical industry are flammable, explosive or toxic dangerous goods, which need to be stored and transported through storage tanks, transportation tankers and other equipment. During the storage process of these equipment, the internal pressure may increase due to increased ambient temperature, direct sunlight or accidental collision, and there is a risk of leakage and explosion. For storage tanks that store organic solvents, the sanitary rupture disk can be used in conjunction with a breathing valve. Under normal circumstances, the breathing valve regulates the pressure balance inside and outside the storage tank. When the pressure rises sharply beyond the regulating capacity of the breathing valve, the sanitary rupture disk immediately ruptures to release the pressure and prevent the storage tank from exploding. In the transportation tank truck, the sanitary rupture disk is installed on the pressure relief device, which can cope with the increase in pressure caused by bumps, collisions and other emergencies during transportation, and ensure transportation safety.
The application of sanitary rupture disk in the pharmaceutical industry covers many aspects of production, storage, transportation, etc., and can provide reliable protection for equipment safety, drug quality, and personnel safety through accurate overpressure and discharge functions.
